Research

Publications

At Usona, our exploration of psychedelic compounds is defined by scientific rigor and discovery. Our Medicinal Chemistry team has published significant research articles in collaboration with scientists around the globe.

Usona Publications

Psilocybin: Characterization of the Metastable Zone Width (MSZW), Control of Anhydrous Polymorphs, and Particle Size Distribution (PSD)

Robert B. Kargbo; Alexander M. Sherwood, Poncho Meisenheimer, Kelsey Lenoch, and Solomon Abebe. 2022
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Psilocybin: crystal structure solutions enable phase analysis of prior art and recently patented examples

A. M. Sherwood, R. B. Kargbo, K. W. Kaylo, N. V. Cozzi, P. Meisenheimer and J. A. Kaduk.
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Structure Elucidation and Spectroscopic Analysis of Chromophors Produced by Oxidative Psilocin Dimerzation

Lenz, C.; Dorner, S.; Hoffmeister, D. Chemistry: A European Journal. 2021.

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Taking Different Roads: I-Tryptophan as the Origin of Psilocybe Natural Products

Lenz, C.; Sherwood, A. M.; Kargbo, R.; Hoffmeister, D. ChemPlus Chem. 2021.

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Scalable Hybrid Synthetic/Biocatalytic Route to Psilocybin

Fricke, J.; Kargbo, R.; Regestein, L.; Lenz, C.; Peschel, G.; Rosenbaum, M.; Sherwood, A.; Hoffmeister, D. Chemistry: A European Journal. 2020.

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Direct Phosphorylation of Psilocin Enables Optimized cGMP Kilogram-Scale Manufacture of Psilocybin

Kargbo, R.B.; Sherwood, A.M.; Walker, A.; Cozzi, N.V.; Dagger, R.E.; Sable, J.; O’Hern,K.; Kaylo,K.; Patterson, T.; Tarpley, G.; Meisenheimer, P. ACS Omega. 2020

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Psilocybin Therapeutic Research: The Present and Future Paradigm

Kargbo, R. B. ACS Medicinal Chemistry Letters. 2020

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Preparation and Characterization of Novel Crystalline Solvates and Polymorphs of Psilocybin and Identification of Solid Forms Suitable for Clinical Development

Greenan, C.; Arlin, J.-B.; Lorimer, K.; Kaylo, K.; Kargbo, R.; Meisenheimer, P.; Tarpley, G.; Sherwood, A. (Preprint – ResearchGate). 2020.

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